The rationale for people with most neurodegenerative disorders, including Parkinson's / Alzheimer's Disease, increasing glutathione is based on the evidence contained in the abstracts & articles below, which describe the role of oxidative stress & the decrease of Glutathione in the brain. Other supporting abstracts can also be found.
Glutathione plays a crucial role in mediating free radical damage & maintaining the oxidant/anti oxidant balance. Since the Brain consumes about 20% of the oxygen utilized by the body, the potential for oxidative stress is high. When glutathione is depleted this tilts the balance in favor of the oxidants - resulting in oxidative stress. Glutathione helps scavenge the free radicals and may slow down the degenerative process in Alzheimer's, Parkinson's Disease, as well as other neurodegenerative disorders.

 

 Metabolism and Functions of Glutathione in Brain

 Glutathione Oxidative Stress and Neurodegeneration

 Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

 Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress.

 Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease.

 The effects of stress and aging on glutathione metabolism

 Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage?

 Parkinson's disease: a disorder due to nigral glutathione deficiency?

 Dopamine turnover and glutathione oxidation: implications for Parkinson disease.

 Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia.

 Glutathione peroxidase in early and advanced Parkinson's disease.

 Reduced intravenous glutathione in the treatment of early Parkinson's disease.

 Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease.

 Glutathione--a review on its role and significance in Parkinson's disease.

 Glutathione and Parkinson's disease: is this the elephant in the room?

 Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

 Neurodegenerative Disorders: GSH Prevention of Neuronal Death.

 Neurodegenerative Diseases - Alzheimer’s and Parkinson’s

 GSH, Dopamine and Glutamate: Roles in Parkinson’s Disease.

 Whey Protein Published Medical Articles Abstract Summary